Welcome to The Qi Lab
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation with bioenergetics defects. Nat Commun, 2019, Mar 26;10(1):1371.
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol, 2019 Mar 15
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nat Commun, 2016 Aug 26;7: 12646.
Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88.
Our laboratory focuses on understanding the roles of mitochondrial quality control and metabolism in neurodegenerative diseases. We use the combination of unbiased proteomics and genomics, cellular and molecular biology, genetic manipulation in vitro and in vivo, patient iPS cells-derived cell culture and diseased animals to investigate the fundamental mechanisms and pathways by which mitochondrial impairment contributes to cellular metabolism disturbance and neurodegeneration. We also utilize rationally designed peptide inhibitors of protein-protein interactions and high throughput screening approach to developing “mitochondrial medicine” as therapeutic strategies for treating neurodegenerative diseases.
Thanks our sponsors for the support!
2109 Adelbert Road, Robbins building E548A-G, Cleveland, Ohio 44106
Office phone: 216-368-4459; Lab phone: 216-368-0886