Publications after joining CWRU (*, Corresponding Author)

Year 2019

Zhao YY, Sun XY, Hu D, Prosdoci D, Jain M, Hoppel C, Ramachandran R, Qi X*, ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation with bioenergetics defects. Nature Communications, 2019, Mar 26;10(1):1371. PDF

Hu D, Sun XY, Zarabi S, Hong YN, Schimmer A, Liao XD, Ford CP, Luo Y, Qi X*, Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathologica, 2019 Mar 15. doi: 10.1007/s00401-019-01993-2. PDF

Zhang XW, Hu D, Shang YT and Qi X*, Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases. BBA-Molecular Basis of Disease, 2019, Mar 18. pii: S0925-4439(19)30078-X. PDF

Fu ZX, Liu F, Jin B, Liu C, Jiang Y, Tang M, and Qi X* and Guo X*. Mutant Huntingtin inhibits mitochondrial unfolded protein response by regulating ABCB10 mRNA stability. BBA-Molecular Basis of Disease, 2019 Feb 22. pii: S0925-4439(19)30067-5. PDF

Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LH, Bechara LRG, Lima VW, Queliconi BB, Disatnik MH, Dourado PM, Kowaltowski AJ, Mochly-Rosen D. Selective antagonism of mitofusin 1-bIIPKC association, SAMbA, is sufficient to improve heart failure outcome. Nature Communications, 2019 Jan 18;10(1):329.

Year 2018

Zhao YY, Sun XY and Qi X*, Inhibition of Drp1 activation reduces mitochondrial damage and neuropathology in zQ175 knock-in mouse model of Huntington’s disease. Biochem Biophys Res Commun., 2018 Dec 9;507(1-4):319-323.

Lu B, Kennedy B, Clinton RW, Wang E, McHugh D, Stepanyants N, Macdonald PJ, Jason A. Mears JA, Qi X and Ramachandran R., Steric interference from intrinsically disordered polypeptide regions controls dynamin-related protein 1 self-assembly during mitochondrial fission. Sci Rep.,  2018 Jul 18;8(1):10879.

Roe AJ and Qi X*, Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington’s disease. Biochem Biophys Res Commun., 2018, Jan 24.

Year 2017

Luo FC, Herrup K, Qi X* and Yang Y*, Inhibition of Drp1 hyperactivation reduces death of oligodendrocytes and enhances functional recovery in experimental models of multiple sclerosis. Exp Neurol., 2017 Feb 24;292:21-34.  [PDF]

Qi X*, eIF2alpha links mitochondrial dysfunction to dendritic degeneration. J Cell Biol., 2017 Mar 6;216(3):555-557.  [PDF]

Guo X and Qi X*, VCP and UBXD1 cooperate to degrade mitochondrial outer membrane protein Mcl1 in model of Huntington’s disease. BBA-Molecular Basis of Disease, 2017 Feb; 1863(2):552-559.  [PDF]

Year 2016

Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X*, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7: 12646.  [PDF]

Disatnik M, Joshi A, Saw N, Shamloo M, Qi X, and Mochly-Rosen D. Potential biomarkers to follow the progression and treatment response of Huntington’s disease. J Exp Med. 2016 Nov 14;213(12):2655-2669.  [PDF]

Filichia E, Hoffer B, Qi X*, Luo Y*, Inhibition of Drp1 mitochondrial translocation provides neuronal protection in dopaminergic system in a Parkinson’s disease model induced by MPTP. Sci Rep., 2016 Sep 13.  [PDF]

Qi X, Davis B, Chiang YH, Filichia E, Barnett A, Greig N, Hoffer B, Luo Y, Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson’s disease model. J Neurochem, 2016 Sep;138(5):746-57.

Klionsky DJ, Abdelmohsen K, Abe A, ··· , Qi X, ··· et al, Guidelines for the use and interpretation of assays for minitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.  [PDF]

Clinton RW, Francy CA, Ramachandran R, Qi X, Mears JA. Dynamin-Related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-Anchored Mitochondrial Fission Factor. J Biol Chem., 2016 Jan 1;291(1):478-92.  [PDF]

Macdonald PJ, Francy CA, Stepanyants N, Lehman L, Baglio A, Mears JA, Qi X, Ramachandran R. Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity. J Biol Chem., 2016 Jan 1;291(1):493-507.  [PDF]

Year 2015

Luo Y, Hoffer A, Hoffer B, Qi X*, Mitochondria: a therapeutic target for Parkinson’s disease? International Journal of Molecular Sciences, 2015 Sep 1;16(9):20704-20730.  [PDF]

Stepanyants N, Macdonald P, Francy CA, Mears J, Qi X and Ramachandran R, Cardiolipin reorganization and phase transition induced by dynamin-related protein 1 promotes mitochondrial membrane fission, Mol Biol Cell, 2015 Sep 1;26(17):3104-16.  [PDF]

Filichia E, Shen H, Zhou X, Qi X, Jin K, Greig N, Hoffer B, Luo Y, Forebrain neuronal specific abalation of p53 gene provides protection in a cortical ischemic stroke model. Neuroscience. 2015 Mar 13.  [PDF]

Su YC, Guo X and Qi X*, Threonine56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. BBA-Molecular Basis of Disease, 2015 Jan;1852(1):12-21.  [PDF]

Year 2014

Guo X, Sesaki H and Qi X*. Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo. Biochem J., 2014 Jul 1;461(1):137-46.  [PDF]

Macdonald PJ, Stepanyants N, Mehrotra N, Mears JA, Qi X, Sesaki H, Ramachandran R, A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol Biol Cell., 2014 Jun 15;25(12):1905-15.  [PDF]

Year 2013

Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X*, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88.  [PDF]

Su YC and Qi X*. Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation. Hum Mol Genet. 2013 Nov 15;22(22): 4545-61. PMID: 23813973.  [PDF]

Mochly-Rosen D, Disatnik M and Qi X, The challenge in translating basic research discoveries to treatment of Huntington’s disease. Rare Dis. 2014 Mar 31;2:e28637. PMID: PMC4091548.  [PDF]

Disatnik M, Ferreira J, Campos JC, Gomes KS, Dourado P, Qi X, and Mochly-Rosen D, Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.  J Am Heart Assoc., 2013 Oct 8;2(5):e000461.  [PDF]

Chang XH, Liang LN, Zhan LB, Lu XG, Shi X, Qi X, Feng ZL, Wu MJ, Sui H, The effect of Jinzhida recipe on the hippocampus in a rat model of diabetes-associated cognitive decline. BMC Complement Altern Med, 2013 Jul 6; 13:161.

Qi X*, Qvit N, Su YC and Mochly-Rosen D. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci. 2013 Feb 1;126 (Pt 3): 789-802.  [PDF]

Su YC and Qi X*. Impairment of Mitochondrial Dynamics: a target for treatment of neurological disorders? Future Neurology, 2013, May 8; 3: 333-346.  [PDF]

Completed publication list